Перегляд за автором "Tsyba, L.O."

Сортувати за: Порядок: Результатів:

  • Alternatively spliced short and long isoforms of adaptor protein intersectin 1 form complexes in mammalian cells 
    Gubar, O.S.; Kropyvko, S.V.; Tsyba, L.O.; Gasman, S.; Rynditch, A.V. (Вiopolymers and Cell, 2012)
    Intersectin 1 (ITSN1) is an adaptor protein involved in membrane trafficking and cell signaling. Long and short isoforms of ITSN1 (ITSN1-L and ITSN1-S) are produced by alternative splicing. The aim of our study was ...
  • Amphiphysin 1 and 2 interact with latent membrane protein 2A of Epstein-Barr virus and regulate its exosomal secretion 
    Dergai, O.V.; Dergai, M.V.; Tsyba, L.O.; Yaruchik, A.M.; Rynditch, A.V.; Skrypkina, I.Ya. (Вiopolymers and Cell, 2012)
    Латентный мембранный белок 2А вируса Эпштейна-Барр является ключевым регулятором латентной фазы вирусной инфек- ции. Цель. Идентифицировать белки, способные связываться с пролин-обогащенными мотивами LMP2A. Методы. Анализ ...
  • Ca/calmodulin-dependent phosphorylation of endocytic scaffold ITSN1 
    Morderer, D.Ye.; Nikolaienko, O.V.; Skrypkina, I.Ya.; Rymarenko, O.V.; Kropyvko, S.V.; Tsyba, L.O.; Rynditch, A.V. (Вiopolymers and Cell, 2014)
    ITSN1 is an endocytic scaffold protein with a prominent function in synaptic transmission. It is known that Ca signaling is crucial for the regulation of synaptic proteins functioning. Aim. Checking the possibility of ...
  • Differential recognition of ITSN2/Ese2 by the SH2 domains of Fyn, Abl1, PLCg1 and PI3KR1 in mouse tissues 
    Novokhatska, O.V.; Pankivskyy, S.V.; Dergai, M.V.; Tsyba, L.O.; Rynditch, A.V. (Вiopolymers and Cell, 2013)
    Phosphorylation of endocytic adaptor ITSN2 that enabled its interaction with the SH2 domains of signaling proteins was recently reported. The aim of this study was to determine whether tissue-specific ITSN2 phosphorylation ...
  • Expression of ITSN2 and TKS5 in different subtypes of breast cancer tumors 
    Kropyvko, S.V.; Tsyba, L.O.; Novokhatska, O.V.; Nemesh, Y.M.; Syvak, L.A.; Tarasenko, T.Ye.; Grabovoy, A.N.; Rynditch, A.V. (Вiopolymers and Cell, 2019)
    Aim. Regardless a great progress in treatment, 15% of breast cancer cases remain lethal. One of the main problems in diagnosis and cure of this cancer type is its high clinical and genetic heterogeneity, and the identification ...
  • Identification and functional analysis of an alternative promoter of human intersectin 1 gene 
    Kropyvko, S.V.; Tsyba, L.O.; Skrypkina, I.Ya.; Rynditch, A.V. (Вiopolymers and Cell, 2010)
    Intersectin 1 (ITSN1) gene encodes an evolutionarily conserved adaptor protein that functions in clathrin-mediated endocytosis, cell signalling, apoptosis and cytoskeleton rearrangements. Its expression is characterized ...
  • Interaction of ubiquitin ligase CBL with LMP2A protein of Epstein-Barr virus occurs via PTB domain of CBL and does not depend on adaptor ITSN1 
    Dergai, O.V.; Dergai, M.V.; Gudkova, D.O.; Tsyba, L.O.; Skrypkina, I.Ya.; Rynditch, A.V. (Вiopolymers and Cell, 2013)
    Aim. Previously Latent membrane protein 2A (LMP2A) of Epstein-Barr virus was found to be ubiquitylated by CBL ubiquitin ligase but no direct interaction of LMP2A with CBL was reported. We aimed to explore this interaction ...
  • ITSN1 and Ruk/CIN85 colocalized to clathrin-coated pits in MCF-7 cells 
    Nikolaienko, O.V.; Skrypkina, I.Ya.; Tsyba, L.O.; Drobot, L.B.; Rynditch, A.V. (Вiopolymers and Cell, 2009)
    Activation of receptor tyrosine kinases (RTK) by corresponding ligands results not only in signal propagation, but also initiates a number of processes, such as clathrin-mediated endocytosis, which precisely regulate ...
  • ITSN protein family: regulation of diversity, role in signalling and pathology 
    Tsyba, L.O.; Dergai, M.V.; Skrypkina, I.Ya.; Nikolaienko, O.V.; Dergai, O.V.; Kropyvko, S.V.; Novokhatska, O.V.; Morderer, D.Ye.; Gryaznova, T.A.; Gubar, O.S.; Rynditch, A.V. (Вiopolymers and Cell, 2013)
    Adaptor/scaffold proteins of the intersectin (ITSN) family are important components of endocytic and signalling complexes. They coordinate trafficking events with actin cytoskeleton rearrangements and modulate the activity ...
  • Novel isoform of adaptor protein ITSN1 forms homodimers via its C-terminus 
    Dergai, M.V.; Dergai, O.V.; Tsyba, L.O.; Novokhatska, O.V.; Skrypkina, I.Ya.; Rynditch, A.V. (Вiopolymers and Cell, 2011)
    Aim. Previously we have identified a novel isoform of endocytic adaptor protein ITSN1 designated as ITSN1- 22a. Western blot revealed two immunoreactive bands of 120 and 250 kDa that corresponded to ITSN1-22a. The goal ...
  • RTK signaling regulator SPRY2 associates with endocytic adaptor ITSN1 in vivo 
    Novokhatska, O.V.; Skrypkina, I.Ya.; Dergai, M.V.; Tsyba, L.O.; Rynditch, A.V. (Вiopolymers and Cell, 2012)
    Передача митогенного сигнала от RTK (рецепторных тирозиновых киназ) тесно связана с эндоцитозом, регулирующим ее точность. Интерсектин 1 (ITSN1) – эволюционно-консервативный адапторный белок, вовлеченный в самые ранние ...